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Introduction: Colorectal poorly differentiated neuroendocrine carcinomas (NECs) are rare, but extremely aggressive. The mechanisms of their carcinogenesis and aggressiveness are still largely unknown. Recently Nobuyoshi Takizawa showed that the molecular features of colorectal NECs are similar to those of adenocarcinoma and not to those of NETs and they were more evident in small cell NECs than in large cell NECs. This is supported by combined cases with conventional adenoma/adenocarcinoma and NECs. Stelow et al showed that DNA mismatch repair proteins were intact in 14/15 colorectal small cell NECs. Two cases of LCNECs arising from SSL have been reported so far in the literature.
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author: Luong T
Keywords: Large cell neuroendocrine carcinoma, sessile serrated lesion, microsatellite instability, MMR protein, BRAF mutation,
Introduction: Microsatellite instability (MSI) has been reported to occur in a significant proportion of neuroendocrine carcinoma (NEC) and mixed adenoneuroendocrine carcinomas (MANEC) (11 out of 89 cases, Sahnane et al, ERC 2015). It might be predictive of response to immunotherapy.
Conference: 14th Annual ENETSConcerence (2017)
Presenting Author: Hadoux J
Authors: Hadoux J, Malka D, Berdeloux A, Planchard D, Boige V,
Keywords: Neuroendocrine carcinoma, mismatch repair, microsatellite instability,
#1087 Gastro-Entero-Pancreatic Mixed Adenoneuroendocrine Tumors. Report of Four Cases.
Introduction: Mixed adenoneuroendocrine carcinomas (MANECs) is an uncommon entity with ill-defined clinicopathologic characteristics.
Conference: 12th Annual ENETSConcerence (2015)
Presenting Author: we do not want to present it orally
Authors: Koletsa T, Iliadis A, Tzioufa V, Karayannopoulou G,
Keywords: Mixed adenoneuroendocrine tumors, immunohistochemistry, MMR proteins, MSI,